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CACNA1C

Description
calcium voltage-gated channel subunit alpha1 C
Aliases
CACH2, CACN2, CACNL1A1, CCHL1A1, CaV1.2, LQT8, TS, TS. LQT8

Gene Identifiers

Entrez ID
775
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_000719.7; NM_001129827.2; NM_001129829.1; NM_001129830.3; NM_001129831.1; NM_001129832.1; NM_001129833.1; NM_001129834.1; NM_001129835.1; NM_001129836.1; NM_001129837.1; NM_001129838.1; NM_001129839.1; NM_001129840.2; NM_001129841.1; NM_001129842.1; NM_001129843.1; NM_001129844.1; NM_001129846.1; NM_001167623.2; NM_001167624.2; NM_001167625.1; NM_199460.3; XM_006719017.2; XM_011521020.2; XM_011521023.3; XM_017019926.2; XM_017019927.2; XM_017019928.2; XM_017019929.2; XM_017019930.2; XM_017019931.2; XM_017019932.2; XM_017019933.2; XM_017019934.2; XM_017019935.2; XM_017019936.2; XM_017019937.2; XM_017019938.2; XM_017019939.2; XM_017019940.2; XM_017019941.2; XM_017019942.2; XM_017019943.2; XM_017019944.2; XM_017019945.2; XM_017019946.2; XM_017019947.2; XM_017019948.2; XM_017019949.2; XM_017019950.2; XM_017019951.2; XM_017019952.2; XM_017019953.1; XM_017019954.1; XM_017019955.2

Protein Identifiers

RefSeq (protein)
NP_000710.5; NP_001123299.1; NP_001123301.1; NP_001123302.2; NP_001123303.1; NP_001123304.1; NP_001123305.1; NP_001123306.1; NP_001123307.1; NP_001123308.1; NP_001123309.1; NP_001123310.1; NP_001123311.1; NP_001123312.1; NP_001123313.1; NP_001123314.1; NP_001123315.1; NP_001123316.1; NP_001123318.1; NP_001161095.1; NP_001161096.2; NP_001161097.1; NP_955630.3; XP_006719080.1; XP_011519322.1; XP_011519325.1; XP_016875415.1; XP_016875416.1; XP_016875417.1; XP_016875418.1; XP_016875419.1; XP_016875420.1; XP_016875421.1; XP_016875422.1; XP_016875423.1; XP_016875424.1; XP_016875425.1; XP_016875426.1; XP_016875427.1; XP_016875428.1; XP_016875429.1; XP_016875430.1; XP_016875431.1; XP_016875432.1; XP_016875433.1; XP_016875434.1; XP_016875435.1; XP_016875436.1; XP_016875437.1; XP_016875438.1; XP_016875439.1; XP_016875440.1; XP_016875441.1; XP_016875442.1; XP_016875443.1; XP_016875444.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
114205
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver, TIME driver
  • Damaged in 496/7921 TCGA samples
  • Damaged in 68/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 25 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 46 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 6/1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials