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Expand for information on CCND1

CCND1

Description
cyclin D1
Aliases
BCL1, D11S287E, PRAD1, U21B31

Gene Identifiers

Entrez ID
595
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
168461
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, healthy and TIME driver
  • Damaged in 536/7921 TCGA samples
  • Damaged in 72/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 237 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 246 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 489/1116 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 2 drugs
  • Response/resistance in 2 cell lines
  • Response/resistance in 0 trials