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Results for CDKN1B


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CDKN1B

Description
cyclin dependent kinase inhibitor 1B
Aliases
CDKN4, KIP1, MEN1B, MEN4, P27KIP1

Gene Identifiers

Entrez ID
1027
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
600778
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor
  • Damaged in 262/7921 TCGA samples
  • Damaged in 11/1291 cell lines

Evolutionary Conservation

  • Metazoans

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 118 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 142 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1121 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 1 cell lines
  • Response/resistance in 0 trials