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Results for CLTC


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CLTC

Description
clathrin heavy chain
Aliases
CHC, CHC17, CLH-17L2, Hc, MRD56, CLTC

Gene Identifiers

Entrez ID
1213
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
118955
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor
  • Damaged in 223/7921 TCGA samples
  • Damaged in 36/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • One duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 389 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 31 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 987/1109 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 2 cell lines
  • Response/resistance in 0 trials