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Results for DNMT3A


Expand for information on DNMT3A

DNMT3A

Description
DNA methyltransferase 3 alpha
Aliases
DNMT3A2, HESJAS, M.HsaIIIA, TBRS

Gene Identifiers

Entrez ID
1788
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
602769
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Cancer gene, healthy driver
  • Damaged in 122/7921 TCGA samples
  • Damaged in 36/1291 cell lines

Evolutionary Conservation

  • Eukaryotes

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 65 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 33 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1115 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials