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Results for FGFR4


Expand for information on FGFR4

FGFR4

Description
fibroblast growth factor receptor 4
Aliases
CD334, JTK2, TKF

Gene Identifiers

Entrez ID
2264
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
134935
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, TIME driver
  • Damaged in 99/7921 TCGA samples
  • Damaged in 23/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 159 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 28 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 2/1112 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 2 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials