Gene query results

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Results for FLCN

Expand for information on FLCN

FLCN

Description

folliculin

Aliases

BHD, DENND8B, FLCL

Gene Identifiers

Entrez ID

201163

Ensembl Gene ID

ENSG00000154803

mRNA Identifiers

RefSeq (mRNA)

NM_001353229.2; NM_001353230.2; NM_001353231.2; NM_144606.7; NM_144997.7; XM_011523714.3; XM_011523718.3; XM_011523719.3; XM_011523721.3; XM_017024305.2; XM_017024308.1; XM_017024309.2; XM_024450635.1

Protein Identifiers

RefSeq (protein)

NP_001340158.1; NP_001340159.1; NP_001340160.1; NP_653207.1; NP_659434.2; XP_011522016.1; XP_011522020.1; XP_011522021.1; XP_011522023.1; XP_016879794.1; XP_016879797.1; XP_016879798.1; XP_024306403.1

Uniprot ID

A0A0S2Z5Y7; Q8NFG4; Q8NFG4; Q8NFG4

Ensembl protein ID

ENSP00000373821.5; ENSP00000285071.4

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

607273

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Tumour suppressor
Damaged in 75/7921 TCGA samples
Damaged in 26/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
43/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1019/1019 in CCLE
No data in CLP
674/675 in GenenTech

Protein Expression in Tissues

45/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 84 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 76 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 10/1116 cell lines

Gene Function

2/6 level 1 KEGG pathways
1/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers