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Results for HIF1A


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HIF1A

Description
hypoxia inducible factor 1 subunit alpha
Aliases
HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78

Gene Identifiers

Entrez ID
3091
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
603348
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, TIME driver
  • Damaged in 69/7921 TCGA samples
  • Damaged in 16/1291 cell lines

Evolutionary Conservation

  • Metazoans

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 396 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 83 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1121 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials