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Results for LATS1

Expand for information on LATS1

LATS1

Description

large tumor suppressor kinase 1

Aliases

WARTS, wts

Gene Identifiers

Entrez ID

9113

Ensembl Gene ID

ENSG00000131023

mRNA Identifiers

RefSeq (mRNA)

NM_001270519.1; NM_001350339.2; NM_001350340.2; NM_001350392.2; NM_004690.4; XM_006715603.3; XM_011536252.2; XM_017011474.1; XM_017011477.1; XM_017011479.1; XM_017011480.1; XM_017011482.1; XM_024446583.1

Protein Identifiers

RefSeq (protein)

NP_001257448.1; NP_001337268.1; NP_001337269.1; NP_001337321.1; NP_004681.1; XP_006715666.1; XP_011534554.1; XP_016866963.1; XP_016866966.1; XP_016866968.1; XP_016866969.1; XP_016866971.1; XP_024302351.1

Uniprot ID

O95835; O95835

Ensembl protein ID

ENSP00000444678.1; ENSP00000437550.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

603473

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Tumour suppressor
Damaged in 108/7921 TCGA samples
Damaged in 34/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
43/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1018/1019 in CCLE
943/970 in CLP
672/675 in GenenTech

Protein Expression in Tissues

44/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 156 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 16 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Not essential in 1088 cell lines

Gene Function

1/6 level 1 KEGG pathways
1/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers