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MAP2K1

Description
mitogen-activated protein kinase kinase 1
Aliases
CFC3, MAPKK1, MEK1, MEL, MKK1, PRKMK1

Gene Identifiers

Entrez ID
5604
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
176872
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, healthy and TIME driver
  • Damaged in 83/7921 TCGA samples
  • Damaged in 22/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • 3 duplicates (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 165 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 52 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 15/1118 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 2 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials