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Results for MAP3K1


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MAP3K1

Description
mitogen-activated protein kinase kinase kinase 1
Aliases
MAPKKK1, MEKK, MEKK 1, MEKK1, SRXY6

Gene Identifiers

Entrez ID
4214
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
600982
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor, TIME driver
  • Damaged in 165/7921 TCGA samples
  • Damaged in 31/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 218 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 40 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1117 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 1 drugs
  • Response/resistance in 1 cell lines
  • Response/resistance in 0 trials