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MAPK1

Description
mitogen-activated protein kinase 1
Aliases
ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK

Gene Identifiers

Entrez ID
5594
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
176948
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, TIME driver
  • Damaged in 101/7921 TCGA samples
  • Damaged in 13/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • One duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 391 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 178 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 27/1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 1 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials