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Results for MBD1


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MBD1

Description
methyl-CpG binding domain protein 1
Aliases
CXXC3, PCM1, RFT

Gene Identifiers

Entrez ID
4152
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_001204136.1; NM_001204137.2; NM_001204138.2; NM_001204139.1; NM_001204140.2; NM_001204141.1; NM_001204142.2; NM_001204143.2; NM_001204151.3; NM_001323942.1; NM_001323947.1; NM_001323949.2; NM_001323950.1; NM_001323951.1; NM_001323952.1; NM_001323953.1; NM_001323954.1; NM_002384.2; NM_015844.2; NM_015845.3; NM_015846.3; NM_015847.3; XM_005258271.3; XM_006722456.3; XM_011525991.2; XM_011525993.3; XM_011525999.2; XM_011526001.2; XM_011526002.2; XM_011526003.3; XM_011526006.2; XM_011526007.2; XM_017025751.2; XM_017025752.2; XM_017025753.2; XM_017025754.2; XM_017025755.2; XM_017025756.2; XM_017025757.2; XM_017025758.2; XM_017025759.2; XM_017025760.2; XM_017025761.2; XM_017025764.2; XM_017025765.2; XM_017025766.2; XM_017025767.2; XM_017025768.2; XM_017025769.2; XM_017025770.2; XM_017025772.2; XM_017025775.2; XM_017025776.2; XM_017025777.2; XM_024451175.1; XM_024451176.1; XM_024451177.1; XM_024451178.1; XM_024451179.1; XM_024451180.1; XM_024451181.1; XM_024451182.1; XM_024451183.1

Protein Identifiers

RefSeq (protein)
NP_001191065.1; NP_001191066.1; NP_001191067.1; NP_001191068.1; NP_001191069.1; NP_001191070.1; NP_001191071.1; NP_001191072.1; NP_001191080.1; NP_001310871.1; NP_001310876.1; NP_001310878.1; NP_001310879.1; NP_001310880.1; NP_001310881.1; NP_001310882.1; NP_001310883.1; NP_002375.1; NP_056669.2; NP_056670.2; NP_056671.2; NP_056723.2; XP_005258328.1; XP_006722519.1; XP_011524293.1; XP_011524295.1; XP_011524301.1; XP_011524303.1; XP_011524304.1; XP_011524305.1; XP_011524308.1; XP_011524309.1; XP_016881240.1; XP_016881241.1; XP_016881242.1; XP_016881243.1; XP_016881244.1; XP_016881245.1; XP_016881246.1; XP_016881247.1; XP_016881248.1; XP_016881249.1; XP_016881250.1; XP_016881253.1; XP_016881254.1; XP_016881255.1; XP_016881256.1; XP_016881257.1; XP_016881258.1; XP_016881259.1; XP_016881261.1; XP_016881264.1; XP_016881265.1; XP_016881266.1; XP_024306943.1; XP_024306944.1; XP_024306945.1; XP_024306946.1; XP_024306947.1; XP_024306948.1; XP_024306949.1; XP_024306950.1; XP_024306951.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
156535
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver, TIME driver
  • Damaged in 75/7921 TCGA samples
  • Damaged in 22/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 46 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 31 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1115 cell lines

Gene Function

  • Not present in KEGG
  • 1/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials