Gene query results

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Results for MEN1

Expand for information on MEN1

MEN1

Description

menin 1

Aliases

MEAI, SCG2

Gene Identifiers

Entrez ID

4221

Ensembl Gene ID

ENSG00000133895

mRNA Identifiers

RefSeq (mRNA)

NM_000244.3; NM_001370251.1; NM_001370259.2; NM_001370260.1; NM_001370261.1; NM_001370262.1; NM_001370263.1; NM_130799.2; NM_130800.2; NM_130801.2; NM_130802.2; NM_130803.2; NM_130804.2; XM_011545040.1; XM_011545041.2; XM_017017765.1; XM_017017766.1; XM_017017767.2; XM_017017768.1

Protein Identifiers

RefSeq (protein)

NP_000235.2; NP_001357180.1; NP_001357188.2; NP_001357189.1; NP_001357190.1; NP_001357191.1; NP_001357192.1; NP_570711.1; NP_570712.1; NP_570713.1; NP_570714.1; NP_570715.1; NP_570716.1; XP_011543342.1; XP_011543343.1; XP_016873254.1; XP_016873255.1; XP_016873256.1; XP_016873257.1

Uniprot ID

A0A024R5D2; O00255; A0A024R5E3; O00255; A0A024R5D2; Q9GZQ5; O00255; A0A024R5D2; Q9GZQ5; O00255; A0A024R5D2; O00255; Q9GZQ5; A0A024R5D2; Q9GZQ5; O00255; O00255; A0A024R5D2; Q9GZQ5

Ensembl protein ID

ENSP00000500585.1; ENSP00000394933.2; ENSP00000413944.2; ENSP00000323747.4; ENSP00000366538.1; ENSP00000308975.6; ENSP00000366530.1; ENSP00000377899.2; ENSP00000337088.1; ENSP00000377901.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

613733

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Tumour suppressor, TIME driver
Damaged in 81/7921 TCGA samples
Damaged in 18/1291 cell lines

Evolutionary Conservation

Eukaryotes

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
41/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1019/1019 in CCLE
938/970 in CLP
675/675 in GenenTech

Protein Expression in Tissues

26/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 80 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 32 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 64/1115 cell lines

Gene Function

1/6 level 1 KEGG pathways
3/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers