Home Query results

Results for MET


Expand for information on MET

MET

Description
MET proto-oncogene, receptor tyrosine kinase
Aliases
AUTS9, DFNB97, HGFR, RCCP2, c-Met

Gene Identifiers

Entrez ID
4233
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
164860
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene, TIME driver
  • Damaged in 218/7921 TCGA samples
  • Damaged in 51/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 167 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 39 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 9/1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 2 drugs
  • Response/resistance in 7 cell lines
  • Response/resistance in 107 trials