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Results for NCOA4


Expand for information on NCOA4

NCOA4

Description
nuclear receptor coactivator 4
Aliases
ARA70, ELE1, PTC3, RFG

Gene Identifiers

Entrez ID
8031
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
601984
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor
  • Damaged in 29/7921 TCGA samples
  • Damaged in 2/1291 cell lines

Evolutionary Conservation

  • Metazoans

Gene Duplication

  • 2 duplicates (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 33 protein(s)
  • Part of zero complexes

miRNA Interactions

  • Interacts with 31 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 27/1115 cell lines

Gene Function

  • 2/6 level 1 KEGG pathways
  • Not present in Reactome

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials