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Results for NTRK1


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NTRK1

Description
neurotrophic receptor tyrosine kinase 1
Aliases
MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA

Gene Identifiers

Entrez ID
4914
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
191315
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene
  • Damaged in 43/7921 TCGA samples
  • Damaged in 8/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 1963 protein(s)
  • Part of at least one complex

miRNA Interactions

  • No miRNA interactions

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 2 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials