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Results for OFD1


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OFD1

Description
OFD1 centriole and centriolar satellite protein
Aliases
71-7A, CXorf5, JBTS10, RP23, SGBS2

Gene Identifiers

Entrez ID
8481
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
300170
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver, TIME driver
  • Damaged in 485/7921 TCGA samples
  • Damaged in 13/1291 cell lines

Evolutionary Conservation

  • Eukaryotes

Gene Duplication

  • One duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 293 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 2 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 5/1050 cell lines

Gene Function

  • Not present in KEGG
  • 3/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials