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Results for PBRM1


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PBRM1

Description
polybromo 1
Aliases
BAF180, PB1

Gene Identifiers

Entrez ID
55193
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_001350074.2; NM_001350075.2; NM_001350076.2; NM_001350077.2; NM_001350078.2; NM_001350079.2; NM_001366070.2; NM_001366071.2; NM_001366072.2; NM_001366073.2; NM_001366074.2; NM_001366075.2; NM_001366076.2; NM_018313.5; NM_181042.5; XM_005265279.5; XM_005265280.3; XM_005265282.4; XM_011533900.3; XM_011533902.3; XM_011533903.3; XM_017006725.1; XM_017006726.1; XM_017006727.1; XM_017006728.1; XM_017006729.2; XM_017006730.1; XM_017006731.1; XM_017006732.1; XM_017006733.2; XM_017006734.2; XM_017006735.2; XM_017006736.1; XM_017006737.1; XM_017006738.2; XM_017006739.1; XM_017006740.1; XM_017006741.2; XM_017006742.1; XM_017006743.2; XM_017006744.1; XM_017006745.2; XM_017006746.2; XM_017006747.1; XM_017006748.1; XM_017006749.1; XM_017006750.1; XM_017006751.2; XM_017006752.1; XM_017006753.2; XM_017006754.1; XM_017006755.2; XM_017006756.2; XM_017006758.1; XM_017006759.2; XM_017006764.2; XM_024453618.1; XM_024453619.1

Protein Identifiers

RefSeq (protein)
NP_001337003.1; NP_001337004.1; NP_001337005.1; NP_001337006.1; NP_001337007.1; NP_001337008.1; NP_001352999.1; NP_001353000.1; NP_001353001.1; NP_001353002.1; NP_001353003.1; NP_001353004.1; NP_001353005.1; NP_060783.3; NP_851385.1; XP_005265336.1; XP_005265337.1; XP_005265339.1; XP_011532202.1; XP_011532204.1; XP_011532205.1; XP_016862214.1; XP_016862215.1; XP_016862216.1; XP_016862217.1; XP_016862218.1; XP_016862219.1; XP_016862220.1; XP_016862221.1; XP_016862222.1; XP_016862223.1; XP_016862224.1; XP_016862225.1; XP_016862226.1; XP_016862227.1; XP_016862228.1; XP_016862229.1; XP_016862230.1; XP_016862231.1; XP_016862232.1; XP_016862233.1; XP_016862234.1; XP_016862235.1; XP_016862236.1; XP_016862237.1; XP_016862238.1; XP_016862239.1; XP_016862240.1; XP_016862241.1; XP_016862242.1; XP_016862243.1; XP_016862244.1; XP_016862245.1; XP_016862247.1; XP_016862248.1; XP_016862253.1; XP_024309386.1; XP_024309387.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
606083
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor, TIME driver
  • Damaged in 281/7921 TCGA samples
  • Damaged in 50/1291 cell lines

Evolutionary Conservation

  • Eukaryotes

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 94 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 22 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 3/1115 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials