Gene query results

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Results for PBX1

Expand for information on PBX1

PBX1

Description

PBX homeobox 1

Aliases

CAKUHED

Gene Identifiers

Entrez ID

5087

Ensembl Gene ID

ENSG00000185630

mRNA Identifiers

RefSeq (mRNA)

NM_001204961.1; NM_001204963.1; NM_001353130.1; NM_001353131.1; NM_002585.4; XM_005245228.3; XM_005245229.3; XM_011509590.2; XM_011509591.2; XM_011509592.2; XM_017001395.2

Protein Identifiers

RefSeq (protein)

NP_001191890.1; NP_001191892.1; NP_001340059.1; NP_001340060.1; NP_002576.1; XP_005245285.1; XP_005245286.1; XP_011507892.1; XP_011507893.1; XP_011507894.1; XP_016856884.1

Uniprot ID

A8K5V0; Q53YC7; P40424; P40424; A0A024R919; A8K5V0; A0A024R919; P40424

Ensembl protein ID

ENSP00000356872.1; ENSP00000485692.1; ENSP00000439943.2; ENSP00000405890.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

176310

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Oncogene
Damaged in 357/7921 TCGA samples
Damaged in 12/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

2 duplicates (60% coverage)

Gene Expression in Tissues

29/30 tissues in GTEx
37/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

602/1019 in CCLE
957/970 in CLP
444/675 in GenenTech

Protein Expression in Tissues

45/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 64 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 14 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 1/1087 cell lines

Gene Function

2/6 level 1 KEGG pathways
2/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers