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PKD1 is a healthy driver


Expand for information on PKD1

PKD1

Description
polycystin 1, transient receptor potential channel interacting
Aliases
PBP, PC1, Pc-1, TRPP1

Gene Identifiers

Entrez ID
5310
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
601313
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Not associated with cancer
  • Healthy driver

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • 2 duplicates (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 44 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 90 miRNAs

Germline Variation vs. Expected

  • No difference
  • No difference
  • No difference

Gene Essentiality

  • Not essential in 1122 cell lines

Gene Function

  • Not present in KEGG
  • 1/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials