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Results for PMS1


Expand for information on PMS1

PMS1

Description
PMS1 homolog 1, mismatch repair system component
Aliases
HNPCC3, MLH2, PMSL1, hPMS1

Gene Identifiers

Entrez ID
Ensembl Gene ID

Protein Architecture

Disease Mapping

COSMIC
OMIM
Pubmed

Druggability

Driver Information

  • Cancer gene
  • Damaged in 77/7921 TCGA samples
  • Damaged in 16/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 82 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 2 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1121 cell lines

Gene Function

  • Not present in KEGG
  • Not present in Reactome

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials