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Results for PMS2

Expand for information on PMS2

PMS2

Description

PMS1 homolog 2, mismatch repair system component

Aliases

HNPCC4, MLH4CL, PMSL2, PMS2

Gene Identifiers

Entrez ID

5395

Ensembl Gene ID

ENSG00000122512

mRNA Identifiers

RefSeq (mRNA)

NM_000535.7; NM_001322003.2; NM_001322004.2; NM_001322005.2; NM_001322006.2; NM_001322007.1; NM_001322008.2; NM_001322009.2; NM_001322010.2; NM_001322011.2; NM_001322012.2; NM_001322013.2; NM_001322014.2; NM_001322015.2; XM_006715744.4; XM_017012342.2; XM_024446800.1

Protein Identifiers

RefSeq (protein)

NP_000526.2; NP_001308932.1; NP_001308933.1; NP_001308934.1; NP_001308935.1; NP_001308936.1; NP_001308937.1; NP_001308938.1; NP_001308939.1; NP_001308940.1; NP_001308941.1; NP_001308942.1; NP_001308943.1; NP_001308944.1; XP_006715807.1; XP_016867831.1; XP_024302568.1

Uniprot ID

B4DGM0; P54278; Q7Z3Q2; Q7Z3Q2; B4DGM0; P54278; P54278; B4DGM0; Q7Z3Q2; P54278; B4DGM0; Q7Z3Q2; P54278; Q7Z3Q2; B4DGM0; C9J167; P54278; B4DGM0; Q7Z3Q2; B4DGM0; Q7Z3Q2; P54278; C9J167; B4DGM0; P54278; Q7Z3Q2; Q7Z3Q2; P54278; B4DGM0; P54278; B4DGM0; Q7Z3Q2; Q7Z3Q2; P54278; B4DGM0; B4DGM0; P54278; Q7Z3Q2; Q7Z3Q2; P54278; B4DGM0; Q7Z3Q2; B4DGM0; P54278

Ensembl protein ID

ENSP00000265849.7; ENSP00000493814.1; ENSP00000495524.1; ENSP00000392843.2; ENSP00000496392.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

600259

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Tumour suppressor
Damaged in 225/7921 TCGA samples
Damaged in 29/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
42/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1019/1019 in CCLE
955/970 in CLP
675/675 in GenenTech

Protein Expression in Tissues

41/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 66 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 2 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Not essential in 1058 cell lines

Gene Function

1/6 level 1 KEGG pathways
3/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers