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Results for POU5F1


Expand for information on POU5F1

POU5F1

Description
POU class 5 homeobox 1
Aliases
OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4

Gene Identifiers

Entrez ID
5460
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
164177
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene
  • Damaged in 10/7921 TCGA samples
  • Damaged in 5/1291 cell lines

Evolutionary Conservation

  • Vertebrates

Gene Duplication

  • 3 duplicates (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 326 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 12 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1007 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials