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Results for RAD51B

Expand for information on RAD51B

RAD51B

Description

RAD51 paralog B

Aliases

R51H2, RAD51L1, REC2

Gene Identifiers

Entrez ID

5890

Ensembl Gene ID

ENSG00000182185

mRNA Identifiers

RefSeq (mRNA)

NM_001321809.1; NM_001321810.1; NM_001321812.1; NM_001321814.1; NM_001321815.1; NM_001321817.2; NM_001321818.1; NM_001321819.1; NM_001321821.1; NM_002877.6; NM_133509.4; NM_133510.4

Protein Identifiers

RefSeq (protein)

NP_001308738.1; NP_001308739.1; NP_001308741.1; NP_001308743.1; NP_001308744.1; NP_001308746.1; NP_001308747.1; NP_001308748.1; NP_001308750.1; NP_002868.1; NP_598193.2; NP_598194.1

Uniprot ID

O15315; C9JYJ0; A0A024R656; O15315; O15315; O15315

Ensembl protein ID

ENSP00000420061.1; ENSP00000419881.1; ENSP00000419471.1; ENSP00000418859.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

602948

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Tumour suppressor
Damaged in 55/7921 TCGA samples
Damaged in 3/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

15/30 tissues in GTEx
40/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

295/1019 in CCLE
953/970 in CLP
519/675 in GenenTech

Protein Expression in Tissues

44/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 42 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 21 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 8/1096 cell lines

Gene Function

1/6 level 1 KEGG pathways
2/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers