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RAF1

Description
Raf-1 proto-oncogene, serine/threonine kinase
Aliases
CMD1NN, CRAF, NS5, Raf-1, c-Raf

Gene Identifiers

Entrez ID
5894
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
164760
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Oncogene
  • Damaged in 83/7921 TCGA samples
  • Damaged in 18/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 258 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 36 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 25/1088 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 3 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials