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Results for RFWD3

Expand for information on RFWD3

RFWD3

Description

ring finger and WD repeat domain 3

Aliases

FANCW, RNF201

Gene Identifiers

Entrez ID

55159

Ensembl Gene ID

ENSG00000168411

mRNA Identifiers

RefSeq (mRNA)

NM_001370534.1; NM_001370535.1; NM_001370536.1; NM_001370537.1; NM_001370539.1; NM_001370540.1; NM_001370542.1; NM_001370543.1; NM_018124.4; XM_005256022.4; XM_006721228.3; XM_011523191.3; XM_017023391.1

Protein Identifiers

RefSeq (protein)

NP_001357463.1; NP_001357464.1; NP_001357465.1; NP_001357466.1; NP_001357468.1; NP_001357469.1; NP_001357471.1; NP_001357472.1; NP_060594.3; XP_005256079.1; XP_006721291.1; XP_011521493.1; XP_016878880.1

Uniprot ID

Q6PCD5; Q6PCD5; Q6PCD5; Q6PCD5

Ensembl protein ID

ENSP00000460049.1; ENSP00000354361.4

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

614151

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Tumour suppressor
Damaged in 38/7921 TCGA samples
Damaged in 12/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
42/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1019/1019 in CCLE
942/970 in CLP
675/675 in GenenTech

Protein Expression in Tissues

21/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 64 protein(s)
Part of zero complexes

miRNA Interactions

Interacts with 31 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 10/1087 cell lines

Gene Function

Not present in KEGG
Not present in Reactome

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers