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Results for RPS6KA3

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RPS6KA3

Description

ribosomal protein S6 kinase A3

Aliases

CLS, HU-3, ISPK-1, MAPKAPK1B, MRX19, RSK, RSK2, S6K-alpha3, p90-RSK2, pp90RSK2

Gene Identifiers

Entrez ID

6197

Ensembl Gene ID

ENSG00000177189

mRNA Identifiers

RefSeq (mRNA)

NM_004586.3; XM_005274573.2; XM_005274577.3; XM_006724507.3; XM_011545555.1; XM_011545556.1; XM_011545557.2; XM_011545558.2; XM_011545560.1; XM_011545561.2; XM_011545562.2; XM_011545563.3; XM_017029713.1; XM_017029714.2; XM_017029715.2; XM_017029716.1; XM_017029717.2; XM_017029718.2; XM_017029719.2

Protein Identifiers

RefSeq (protein)

NP_004577.1; XP_005274630.1; XP_005274634.1; XP_006724570.1; XP_011543857.1; XP_011543858.1; XP_011543859.1; XP_011543860.1; XP_011543862.1; XP_011543863.1; XP_011543864.1; XP_011543865.1; XP_016885202.1; XP_016885203.1; XP_016885204.1; XP_016885205.1; XP_016885206.1; XP_016885207.1; XP_016885208.1

Uniprot ID

P51812; B4DG22; B7ZB17; B7ZB17; B7ZB17; B7ZB17; B7ZB17; B7ZB17; B4DG22

Ensembl protein ID

ENSP00000368884.3; ENSP00000495974.1; ENSP00000496271.1; ENSP00000494220.1; ENSP00000494769.1; ENSP00000493862.1; ENSP00000495462.1; ENSP00000407655.2

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

300075

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Candidate cancer driver, TIME driver
Damaged in 488/7921 TCGA samples
Damaged in 14/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

2 duplicates (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
43/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1018/1019 in CCLE
929/970 in CLP
674/675 in GenenTech

Protein Expression in Tissues

45/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 118 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 48 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Equal damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 1/1114 cell lines

Gene Function

4/6 level 1 KEGG pathways
5/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 0 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers