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Results for SIRPA


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SIRPA

Description
signal regulatory protein alpha
Aliases
BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP

Gene Identifiers

Entrez ID
140885
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
602461
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor
  • Damaged in 22/7921 TCGA samples
  • Damaged in 10/1291 cell lines

Evolutionary Conservation

  • Vertebrates

Gene Duplication

  • 2 duplicates (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 78 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 43 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Not essential in 1122 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials