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SMAD2

Description
SMAD family member 2
Aliases
JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2

Gene Identifiers

Entrez ID
4087
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
601366
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor, TIME driver
  • Damaged in 106/7921 TCGA samples
  • Damaged in 21/1291 cell lines

Evolutionary Conservation

  • Metazoans

Gene Duplication

  • One duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 395 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 76 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 1/1115 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials