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STAG2

Description
stromal antigen 2
Aliases
HPE13, MKMS, NEDXCF, SA-2, SA2, SCC3B, bA517O1.1

Gene Identifiers

Entrez ID
10735
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
300826
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor, healthy and TIME driver
  • Damaged in 657/7921 TCGA samples
  • Damaged in 42/1291 cell lines

Evolutionary Conservation

  • Eukaryotes

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 85 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 15 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 95/993 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 12 cell lines
  • Response/resistance in 0 trials