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Results for STK11


Expand for information on STK11

STK11

Description
serine/threonine kinase 11
Aliases
LKB1, PJS, hLKB1

Gene Identifiers

Entrez ID
6794
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)

Protein Identifiers

RefSeq (protein)
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
602216
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Tumour suppressor, TIME driver
  • Damaged in 117/7921 TCGA samples
  • Damaged in 64/1291 cell lines

Evolutionary Conservation

  • Last Universal Common Ancestor

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 235 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 38 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Fewer damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 36/1121 cell lines

Gene Function

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 1 cell lines
  • Response/resistance in 0 trials