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Results for TCF4


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TCF4

Description
transcription factor 4
Aliases
CDG2T, E2-2, FECD3, ITF-2, ITF2, PTHS, SEF-2, SEF2, SEF2-1, SEF2-1A, SEF2-1B, SEF2-1D, TCF-4, bHLHb19

Gene Identifiers

Entrez ID
6925
Ensembl Gene ID

mRNA Identifiers

RefSeq (mRNA)
NM_001083962.2; NM_001243226.3; NM_001243227.2; NM_001243228.2; NM_001243230.1; NM_001243231.2; NM_001243232.1; NM_001243233.2; NM_001243234.2; NM_001243235.2; NM_001243236.2; NM_001306207.1; NM_001306208.1; NM_001330604.3; NM_001330605.3; NM_001348211.2; NM_001348212.2; NM_001348213.2; NM_001348214.2; NM_001348215.2; NM_001348216.2; NM_001348217.1; NM_001348218.2; NM_001348219.2; NM_001348220.1; NM_001369567.1; NM_001369568.1; NM_001369569.1; NM_001369570.1; NM_001369571.1; NM_001369572.1; NM_001369573.1; NM_001369574.1; NM_001369575.1; NM_001369576.1; NM_001369577.1; NM_001369578.1; NM_001369579.1; NM_001369580.1; NM_001369581.1; NM_001369582.1; NM_001369583.1; NM_001369584.1; NM_001369585.1; NM_001369586.1; NM_003199.3; XM_005266749.4; XM_005266752.5; XM_005266755.5; XM_005266761.4; XM_006722538.3; XM_017025950.2; XM_017025951.2; XM_017025952.2; XM_017025953.2; XM_017025954.2; XM_017025956.2; XM_024451241.1

Protein Identifiers

RefSeq (protein)
NP_001077431.1; NP_001230155.2; NP_001230156.1; NP_001230157.1; NP_001230159.1; NP_001230160.1; NP_001230161.1; NP_001230162.1; NP_001230163.1; NP_001230164.1; NP_001230165.1; NP_001293136.1; NP_001293137.1; NP_001317533.1; NP_001317534.1; NP_001335140.1; NP_001335141.1; NP_001335142.1; NP_001335143.1; NP_001335144.1; NP_001335145.1; NP_001335146.1; NP_001335147.1; NP_001335148.1; NP_001335149.1; NP_001356496.1; NP_001356497.1; NP_001356498.1; NP_001356499.1; NP_001356500.1; NP_001356501.1; NP_001356502.1; NP_001356503.1; NP_001356504.1; NP_001356505.1; NP_001356506.1; NP_001356507.1; NP_001356508.1; NP_001356509.1; NP_001356510.1; NP_001356511.1; NP_001356512.1; NP_001356513.1; NP_001356514.1; NP_001356515.1; NP_003190.1; XP_005266806.1; XP_005266809.1; XP_005266812.1; XP_005266818.1; XP_006722601.1; XP_016881439.1; XP_016881440.1; XP_016881441.1; XP_016881442.1; XP_016881443.1; XP_016881445.1; XP_024307009.1
Uniprot ID
Ensembl protein ID

Protein Architecture

SMART
domain composition

Disease Mapping

COSMIC
cancer mutations
OMIM
602272
Pubmed
Literature

Druggability

DGIdb
drugs
STITCH
compound interactions
CTD
interacting chemicals

Driver Information

  • Candidate cancer driver, TIME driver
  • Damaged in 91/7921 TCGA samples
  • Damaged in 19/1291 cell lines

Evolutionary Conservation

  • Metazoans

Gene Duplication

  • No duplicate (60% coverage)

Gene Expression in Tissues

Gene Expression in Cell Lines

Protein Expression in Tissues

Protein Interactions

  • Interacts with 283 protein(s)
  • Part of at least one complex

miRNA Interactions

  • Interacts with 15 miRNAs

Germline Variation vs. Expected

  • Fewer loss of function mutations
  • Equal damaging SNVs/indels
  • Fewer structural variants

Gene Essentiality

  • Essential in 2/1121 cell lines

Gene Function

  • Not present in KEGG
  • 1/26 level 1 Reactome pathways

Drug Target/Biomarker

  • Targeted by 0 drugs
  • Response/resistance in 0 cell lines
  • Response/resistance in 0 trials