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Results for TSC2

Expand for information on TSC2

TSC2

Description

TSC complex subunit 2

Aliases

LAM, PPP1R160, TSC4

Gene Identifiers

Entrez ID

7249

Ensembl Gene ID

ENSG00000103197

mRNA Identifiers

RefSeq (mRNA)

NM_000548.5; NM_001077183.2; NM_001114382.2; NM_001318827.1; NM_001318829.1; NM_001318831.1; NM_001318832.1; NM_001363528.1; NM_001370404.1; NM_001370405.1; NM_021055.2; XM_011522636.2; XM_011522637.2; XM_011522638.2; XM_011522639.2; XM_011522640.2; XM_017023615.1; XM_017023618.1; XM_024450413.1

Protein Identifiers

RefSeq (protein)

NP_000539.2; NP_001070651.1; NP_001107854.1; NP_001305756.1; NP_001305758.1; NP_001305760.1; NP_001305761.1; NP_001350457.1; NP_001357333.1; NP_001357334.1; NP_066399.2; XP_011520938.1; XP_011520939.1; XP_011520940.2; XP_011520941.1; XP_011520942.1; XP_016879104.1; XP_016879107.1; XP_024306181.1

Uniprot ID

P49815; X5D7Q2; P49815; P49815; P49815; P49815; B3KWH7; P49815; Q5HYF7; H3BMQ0; P49815

Ensembl protein ID

ENSP00000219476.3; ENSP00000384468.2; ENSP00000344383.4; ENSP00000399232.2; ENSP00000371978.6; ENSP00000454487.1; ENSP00000493846.1; ENSP00000494514.1; ENSP00000495099.1; ENSP00000496262.1; ENSP00000495921.1; ENSP00000495459.1; ENSP00000496611.1

Protein Architecture

SMART

domain composition

Disease Mapping

COSMIC

cancer mutations

OMIM

191092

Pubmed

Literature

Druggability

DGIdb

drugs

STITCH

compound interactions

CTD

interacting chemicals

Driver Information

Tumour suppressor, TIME driver
Damaged in 164/7921 TCGA samples
Damaged in 40/1291 cell lines

Evolutionary Conservation

Last Universal Common Ancestor

Gene Duplication

No duplicate (60% coverage)

Gene Expression in Tissues

30/30 tissues in GTEx
43/43 tissues in The Protein Atlas

Gene Expression in Cell Lines

1018/1019 in CCLE
956/970 in CLP
675/675 in GenenTech

Protein Expression in Tissues

30/45 tissues in The Protein Atlas

Protein Interactions

Interacts with 119 protein(s)
Part of at least one complex

miRNA Interactions

Interacts with 3 miRNAs

Germline Variation vs. Expected

Fewer loss of function mutations
Fewer damaging SNVs/indels
Fewer structural variants

Gene Essentiality

Essential in 31/1122 cell lines

Gene Function

4/6 level 1 KEGG pathways
5/26 level 1 Reactome pathways

Drug Target/Biomarker

Targeted by 0 drugs
Response/resistance in 0 cell lines
Response/resistance in 1 trials

NCG7.1

Network of Cancer Genes & Healthy Drivers